Network-based gene-disease prioritization using PROPHNET
نویسندگان
چکیده
منابع مشابه
Network-based gene-disease prioritization using PROPHNET
Motivation and Objectives A major goal in biomedicine is to determine the underlying genetic causes of human diseases in order to better understand them and support their prevention and treatment. However, the genetic bases of many multifactorial diseases are still unclear, and high-throughput technologies typically report hundred or thousands of genes associated to a disease of interest. In th...
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Assisting drug repositioning processes can lead to a considerable reduction in cost and time in any drug development process. Recent in silico approaches have addressed the network-based nature of biological information to assess the possible new indications for a query drug. Here we present a new methodology based on network prioritization, that can aid researchers in the drug repositioning pr...
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We present a new gene prioritization method that learns a probabilistic knowledge model from a knowledge base and free text research documents and exploits it to prioritize candidate genes. The knowledge model is represented by a network of associations among the domain entities (e.g., genes) and is extracted from a domain knowledge base (e.g., protein-protein interaction database) or a corpus ...
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ژورنال
عنوان ژورنال: EMBnet.journal
سال: 2012
ISSN: 2226-6089
DOI: 10.14806/ej.18.b.543